Somebody must be able to tell us more about H.E. Bucklin aka Bucklen. He had bottles of patent medicine widely distributed in the United States that bore the name of his company.  For example, here the label of one kept in the Smithsonian National Museum of Natural History

The product was sold for "temporary constipation and biliousness."  It contained the serious sounding ingredients of: Cascara, Podophyllin, Aloin, Strychnine Sulphate, and Capsicum Maker(s).

The library at the University of Florida has a copy of the HE Bucklen Almanacs for years of 1909, 1910, 1912, 1913, and 1914.  the almanacs for 1909 through 1913 say Chicago for the place of business of the company, but the the 1914 says St Louis, which gives us a good indication of when the Company relocated to St Louis.

One of the more popular patent medicines, sold for 60 cents about 1900, in a large bottle, was the "Electric Brand Laxative, Formerly called Electric Brand Bitters. . .  A Family laxative contains Senna, Rhubarb, Cascara, Sagrada, Hops, Aloes, Wahoo, Dandelion, Gentian, Uva Ursi, Tansey, Chamomile and Quassia, Combined with Aromatics."  The choice ingredient seems to have been  ALCOHOL at the 18% level.

Herbert E. Bucklen purchased a line of medicines from Dr. Z. L. King and moved from Elkhart, Indiana to Chicago, Ill about 1878-1879. Bucklen spent lavish sums on advertising and created the "New Discovery" as a nationally known brand by 1885. He also had several other top selling medicines including Dr. King's New Life Pills and his Electric Bitters. The "New Discovery" was a medicine for consumption (Tuberculosis) which at the time was killing millions of people. Many companies offered cures and remedies for consumption all were frauds. the "New Discovery" was targeted by Samuel Hopkins Adams in his attack on the patent medicine industry in a series of articles in Colliers Magazine in 1905. Of the 'New Discovery," Adams said, "It is proclaimed to be the 'only sure cure for consumption.' Further announcement is made that 'it strikes terror to the doctors.' As it is a morphine and chloroform mixture, 'Dr. King's New discovery for Consumption' is well calculated to strike terror to the doctors or to any other class or profession, except, perhaps, the undertakers. It is a pretty diabolical concoction to give to anyone, and particularly to a consumptive. The chloroform temporarily allays the cough, thereby checking Nature's effort to throw off the dead matter from the lungs. the opium drugs the patient into a deceived cheerfulness. The combination is admirably designed to shorten the life of any consumptive who takes it steadily."

H.E. Bucklen & Company of Chicago were highly successful sellers of a number of well-known brands. The biggest seller was their Dr. King's New Discovery, a cure for consumption (TB). Another highly successful product of theirs was Electric Bitters. Other product which never sold well were Dr. King's California Golden Compound. Dr. King's Hop Cordial and Dr. Scheeler's Great German Cure for Consumption..

Herbert E. Bucklen purchased the rights to the medicines from one Dr. Z.L. King of Elkhart Indiana about 1878 and moved to Chicago the next year. He created name recognition by the expenditure of large sums on advertising in all types of media. the New Life Pills were introduced in 1880 as a cure for stomach ailments

By 1893, the business was well enough established to offer for 50 cents a 31 page book, half filled with color lithographs of the world fair buildings, and the other half descriptive text.